Andrew Tidball
Research Assistant Professor of Neurology, University of Michigan Medical School
Dr. Andrew Tidball is a Research Assistant Professor in the Department of Neurology at the University of Michigan Medical School University of Michigan Medical School and a Center Member of the Center for Cell Plasticity and Organ Design University of Michigan Medical School. He earned his Ph.D. from Vanderbilt University in 2014 and his B.S. from Calvin College in 2008 University of Michigan Medical School.
Dr. Tidball's research focuses on developing innovative human induced pluripotent stem cell (iPSC) models and organoid systems to study neurological diseases, particularly genetic epilepsies and neural tube defects. His lab has pioneered novel organoid techniques, including the development of self-organizing, single-rosette spheroids (SOSRS) with reproducible morphology for studying brain development and disease mechanisms. Recently, his groundbreaking work identified lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) as universal apical polarity cues that enable "inside-out" organoid orientation across multiple tissue types, revolutionizing high-resolution imaging approaches.
His work bridges stem cell biology, neuroscience, and molecular genetics to create patient-derived disease models that advance mechanistic understanding and enable precision therapeutic discovery for conditions including epileptic encephalopathies, neural tube defects, and other neurodevelopmental disorders.
